PSMD9
Description
The PSMD9 (proteasome 26S subunit, non-ATPase 9) is a protein-coding gene located on chromosome 12.
PSMD9, or 26S proteasome non-ATPase regulatory subunit 9, is an enzyme encoded by the PSMD9 gene in humans. It is a component of the 26S proteasome, a large protein complex responsible for degrading proteins in cells. The 26S proteasome consists of two main parts: a 20S core and a 19S regulator. The 20S core breaks down proteins into peptides, while the 19S regulator recognizes and delivers proteins to the 20S core. PSMD9 is a non-ATPase subunit of the 19S regulator, meaning it does not use energy from ATP to function. The proteasome and its subunits are crucial for cellular processes and are involved in various diseases. A dysfunctional proteasome can lead to disease development, and the proteasome is a target for drug development. Understanding the proteasome's functions and its role in disease could lead to new diagnostic tools and treatment strategies.
PSMD9 acts as a chaperone during the assembly of the 26S proteasome, specifically aiding in the formation of the base subcomplex of the PA700/19S regulatory complex (RC). During this process, PSMD9 forms an intermediate complex with PSMC6 and PSMC3, known as the modulator trimer complex. PSMD9 is released from this complex as the base subcomplex assembly progresses.
PSMD9 is also known as Rpn4, p27.
