PSMD7
Description
The PSMD7 (proteasome 26S subunit, non-ATPase 7) is a protein-coding gene located on chromosome 16.
PSMD7, also known as 26S proteasome non-ATPase regulatory subunit 7 or RPN8, is an enzyme encoded by the PSMD7 gene in humans. It is a subunit of the 19S regulatory particle (RP) within the 26S proteasome, a complex responsible for degrading proteins. The 26S proteasome consists of two parts: the 20S core particle (CP) and the 19S RP. The 20S core has 28 subunits arranged in four rings, while the 19S RP has a base with 6 ATPase subunits and a lid with non-ATPase subunits, including PSMD7. PSMD7 is a 37 kDa protein with 324 amino acids. The PSMD7 gene has 7 exons and is located on chromosome 16 at band 16q22.3. A pseudogene for PSMD7 is found on chromosome 17.
PSMD7 is a component of the 26S proteasome, a multiprotein complex responsible for breaking down ubiquitinated proteins. This process is crucial for maintaining protein quality control, removing damaged or misfolded proteins that could disrupt cellular function. The 26S proteasome also plays a role in removing proteins no longer needed by the cell, contributing to various cellular processes such as cell cycle control, apoptosis (programmed cell death), and DNA repair.
PSMD7 is also known as MOV34, P40, Rpn8, S12.
