PSMD5-AS1
Unveiling the Intriguing World of PSMD5-AS1 Gene
Description
The PSMD5-AS1 gene, located on human chromosome 12q24.11, encodes an antisense RNA molecule that regulates the expression of the PSMD5 gene. PSMD5, also known as the 26S protease regulatory subunit 5, plays a crucial role in the degradation of ubiquitinated proteins by the proteasome, a molecular machine responsible for cellular protein turnover.
Associated Diseases
Mutations or dysregulation of PSMD5-AS1 have been linked to several diseases, including:
- Lung cancer: Reduced PSMD5-AS1 expression has been associated with increased lung cancer cell proliferation and invasion.
- Esophageal cancer: Low PSMD5-AS1 levels correlate with poor prognosis and increased tumor growth in esophageal cancer patients.
- Gastric cancer: Overexpression of PSMD5-AS1 has been linked to increased cell proliferation and tumor metastasis in gastric cancer.
- Colorectal cancer: PSMD5-AS1 may contribute to cell migration and invasion in colorectal cancer, promoting tumor progression.
- Neurological disorders: PSMD5-AS1 dysfunction has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Did you Know ?
According to a recent study published in the journal "Cancer Research," patients with lung cancer who had low PSMD5-AS1 expression had a 5-year survival rate of only 35%, compared to 65% for those with high PSMD5-AS1 expression.
