PSMD5
Description
The PSMD5 (proteasome 26S subunit, non-ATPase 5) is a protein-coding gene located on chromosome 9.
PSMD5 is a gene that encodes the 26S proteasome non-ATPase regulatory subunit 5, an enzyme involved in protein degradation. The 26S proteasome is a complex structure made of two main parts: a 20S core and a 19S regulator. PSMD5 is part of the 19S regulator, specifically the base subcomplex, which helps to regulate the activity of the proteasome. The proteasome and its subunits are important for a variety of cellular functions and are involved in disease processes. For example, dysfunctions in the proteasome can contribute to the development of certain diseases. The proteasome is also a potential target for therapeutic interventions.
PSMD5 acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). It forms an intermediate module with PSMC2, PSMC1, and PSMD2 in the initial step of base subcomplex assembly. This module then likely assembles with another module containing PSMD10, PSMC4, PSMC5, and PAAF1. PSMD5 then dissociates from the complex.
PSMD5 is also known as S5B.
