PSMB2

Description

The PSMB2 (proteasome 20S subunit beta 2) is a protein-coding gene located on chromosome 1.

Proteasome subunit beta type-2, also known as 20S proteasome subunit beta-4 (based on systematic nomenclature), is a protein encoded by the PSMB2 gene in humans. It's one of the 17 essential subunits contributing to the complete assembly of the 20S proteasome complex. PSMB2, along with other beta subunits, assembles into two heptameric rings, forming a proteolytic chamber for substrate degradation. The eukaryotic proteasome recognizes degradable proteins, including damaged proteins for quality control and key regulatory proteins for biological processes. A modified proteasome, the immunoproteasome, plays a crucial role in processing class I MHC peptides. The PSMB2 gene encodes a member of the proteasome B-type family (T1B family) and is located at chromosome band 1p34.2, spanning 7 exons. The human PSMB2 protein is 23 kDa in size, composed of 201 amino acids, with a theoretical pI of 6.52. The proteasome is a multicatalytic proteinase complex with a highly ordered 20S core structure.

PSMB2 is a non-catalytic component of the 20S core proteasome complex, essential for the degradation of most intracellular proteins. It participates in various cellular processes by associating with different regulatory particles. When bound to two 19S regulatory particles, it forms the 26S proteasome, which degrades ubiquitinated proteins in an ATP-dependent manner. The 26S proteasome is crucial for maintaining protein homeostasis by removing misfolded or damaged proteins and those no longer needed. In association with PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation, essential for processes like spermatogenesis (20S-PA200 complex) and the generation of certain MHC class I-presented antigenic peptides (20S-PA28 complex).

PSMB2 is also known as HC7-I.

Associated Diseases

WES Whole Exome Sequencing