PSG9
Description
The PSG9 (pregnancy specific beta-1-glycoprotein 9) is a protein-coding gene located on chromosome 19.
Pregnancy-specific beta-1-glycoprotein 9 is a protein that in humans is encoded by the PSG9 gene.
PSG9, also known as PS34, Pregnancy-specific beta-1 glycoprotein B, Pregnancy-specific beta-1-glycoprotein 11, and Pregnancy-specific glycoprotein 7, binds to the small latent transforming growth factor-beta complex. This complex consists of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1. PSG9 binding activates TGFB1, which in turn stimulates naive CD4(+) T-cells to increase FoxP3 expression and the number of FoxP3(+) regulatory T-cells. PSG9 also induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset and the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells. It may reduce the expression of pro-inflammatory cytokines and chemokines, including IL2 and IL6, by CD4(+) T-cells.
PSG9 is also known as PS34, PSBG-11, PSBG-9, PSG11, PSGII.
Associated Diseases
- thyroid gland adenocarcinoma
- low grade glioma
- obesity due to melanocortin 4 receptor deficiency
- LIPE-related familial partial lipodystrophy
- obesity due to leptin receptor gene deficiency
- PLIN1-related familial partial lipodystrophy
- CIDEC-related familial partial lipodystrophy
- AXIN2-related attenuated familial adenomatous polyposis
- obesity due to prohormone convertase I deficiency
- obesity due to pro-opiomelanocortin deficiency
- obesity due to congenital leptin deficiency
- Muir-Torre syndrome
- short stature due to primary acid-labile subunit deficiency
- AKT2-related familial partial lipodystrophy
- familial partial lipodystrophy, Kobberling type
- familial partial lipodystrophy, Dunnigan type
- Hirschsprung disease
