PRRC2A
Description
The PRRC2A (proline rich coiled-coil 2A) is a protein-coding gene located on chromosome 6.
PRRC2A is a protein encoded by the BAT2 gene. It is located within the human major histocompatibility complex class III region, alongside other genes like TNF alpha and TNF beta. PRRC2A contains microsatellite repeats that may be associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and could contribute to pancreatic beta-cell destruction during IDDM development. This gene is also considered a candidate for rheumatoid arthritis development. There are two alternatively spliced transcripts encoding different isoforms of PRRC2A. PRRC2A has been shown to interact with C1QBP, EIF3S6, HNRNPA1, IFT88, IMMT, and UBAP2L.
May play a role in the regulation of pre-mRNA splicing.
PRRC2A is also known as BAT2, D6S51, D6S51E, G2.
