PRR5
Description
The PRR5 (proline rich 5) is a protein-coding gene located on chromosome 22.
PRR5 is a component of the mTORC2 complex, which plays a critical role in regulating cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors but is not affected by nutrient levels. It influences the actin cytoskeleton by acting upstream of Rho GTPases, potentially through activation of Rho-type guanine nucleotide exchange factors. This complex promotes the formation of stress fibers and F-actin in response to serum. mTORC2 is essential for the phosphorylation of AKT1 at serine 473, facilitating subsequent phosphorylation of threonine 308 by PDK1, which is crucial for full AKT1 activation. It also regulates the phosphorylation of SGK1 at serine 422 and PRKCA at serine 657. PRR5 is involved in the regulation of PDGFRB expression and modulates platelet-derived growth factor signaling. It may have tumor suppressor activity in breast cancer.
PRR5 is also known as FLJ20185k, PP610, PROTOR-1, PROTOR1.
Associated Diseases
- endometrial cancer
- urinary bladder cancer
- cholesterol-ester transfer protein deficiency
- hypertriglyceridemia 2
- homozygous familial hypercholesterolemia
- sitosterolemia
- thyroid hormone metabolism, abnormal, 2
- bipolar disorder
- cancer
