PROCR
Description
The PROCR (protein C receptor) is a protein-coding gene located on chromosome 20.
PROCR, also known as endothelial protein C receptor (EPCR) or activated protein C receptor (APC receptor), is a transmembrane glycoprotein receptor encoded by the PROCR gene. Its function is primarily related to the regulation of blood coagulation, inflammation, and vascular integrity. PROCR is crucial for maintaining homeostasis by enhancing the anticoagulant activity of protein C, modulating inflammatory responses, and contributing to endothelial barrier function. The protein is characterized by an extracellular domain containing a high-affinity binding site for activated protein C (APC), a transmembrane domain, and a cytoplasmic tail. PROCR is expressed on endothelial cells, which line blood vessels, and has also been identified as a hematopoietic stem cell (HSC) marker. Its main function is to facilitate the anticoagulant activity of APC by binding to it on the surface of endothelial cells.
PROCR is also known as CCCA, CCD41, EPCR.
