PRND
Description
The PRND (prion like protein doppel) is a protein-coding gene located on chromosome 20.
Prion protein 2 (dublet), also known as PRND or Doppel protein, is a protein encoded by the PRND gene in humans. This gene is located on chromosome 20, near the gene for cellular prion protein. The PRND protein is a membrane-bound glycoprotein anchored to the cell membrane by glycosylphosphatidylinositol (GPI). It is primarily found in the testes. Mutations in the PRND gene can lead to neurological disorders.
PRND is required for normal acrosome reaction and male fertility. It can bind copper ions (Cu2+).
PRND is also known as DOPPEL, DPL, PrPLP, dJ1068H6.4.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 20
- spermatogenic failure 5
- spermatogenic failure 26
- spermatogenic failure 31
- spermatogenic failure 72
- spermatogenic failure 46
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure, X-linked, 3
- spermatogenic failure 65
- spermatogenic failure 40
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 47
- spermatogenic failure 45
- spermatogenic failure 43
- spermatogenic failure 19
- spermatogenic failure 49
- partial chromosome Y deletion
