PRMT2
PRMT2 Gene: Unveiling its Role in Health and Disease
Introduction
The PRMT2 gene, located on chromosome 4q31.1, plays a pivotal role in various cellular processes. It encodes an enzyme called protein arginine methyltransferase 2 (PRMT2), which modifies proteins by adding methyl groups to arginine residues. This modification, known as arginine methylation, regulates protein function and stability.
Description
PRMT2 is composed of 453 amino acids and belongs to the PRMT family of enzymes. It primarily methylates arginine residues in the context of glycine and arginine-rich (GAR) motifs. This methylation adds a single methyl group to the nitrogen atom of the arginine residue.
Associated Diseases
Aberrant PRMT2 activity has been implicated in several diseases, including:
- Cancer: PRMT2 overexpression is associated with increased cell proliferation, invasion, and metastasis in various cancers, such as leukemia, breast cancer, and lung cancer.
- Neurological Disorders: PRMT2 dysfunction has been linked to neurodevelopmental disorders such as intellectual disability and autism spectrum disorder.
- Cardiovascular Diseases: Altered PRMT2 activity has been connected to cardiac hypertrophy, heart failure, and endothelial dysfunction.
- Inflammatory Diseases: PRMT2 methylation of inflammatory mediators regulates their activity and contributes to the development of conditions like rheumatoid arthritis and asthma.
Did you Know ?
Research suggests that PRMT2 overexpression occurs in approximately 30% of acute myeloid leukemia cases, highlighting its significant role in cancer.
