PRLH
The PRL Gene: Unlocking the Secrets of Reproduction and Growth
Description:
The PRL gene, located on chromosome 6, plays a crucial role in human reproduction and growth. It encodes the hormone prolactin (PRL), which is primarily responsible for stimulating the production of breast milk in women after childbirth. However, PRL also has additional functions, including regulating reproductive cycles, growth and development, and immune responses.
Associated Diseases:
Mutations or variations in the PRL gene can lead to various medical conditions, including:
- Hyperprolactinemia: Excess PRL secretion, which can disrupt reproductive function, cause infertility, and lead to other symptoms such as amenorrhea (absence of menstrual periods), galactorrhea (breast milk production outside of pregnancy), and headaches.
- Infertility: Reduced or absent PRL levels can impair fertility in both men and women.
- Growth hormone deficiency: PRL can stimulate the production of growth hormone, so deficiencies in PRL can result in stunted growth.
- Immune disorders: PRL has immunomodulatory effects, and alterations in its levels can affect immune function.
Did you Know ?
Hyperprolactinemia, the most common PRL-related disorder, affects approximately 0.4-9.5% of women and 0.2-0.4% of men in the general population.
