PRKAR2B
Description
The PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta) is a protein-coding gene located on chromosome 7.
The PRKAR2B gene encodes cAMP-dependent protein kinase type II-beta regulatory subunit, an enzyme involved in various cellular functions. cAMP, a signaling molecule, activates the cAMP-dependent protein kinase (PKA), which then phosphorylates target proteins. PKA is inactive as a tetramer composed of two regulatory and two catalytic subunits. cAMP promotes the dissociation of this inactive form into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Humans have four regulatory subunits and three catalytic subunits of PKA, and PRKAR2B is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit and has been shown to interact with and suppress the transcriptional activity of CREB1 in activated T cells. Knockout studies in mice suggest that PRKAR2B may play a significant role in regulating energy balance and adiposity.
PRKAR2B, a regulatory subunit of the cAMP-dependent protein kinases, plays a critical role in cAMP signaling within cells. Type II regulatory chains, like PRKAR2B, facilitate membrane association by binding to anchoring proteins such as MAP2 kinase.
PRKAR2B is also known as PRKAR2, RII-BETA.
Associated Diseases
- ovarian cancer
- esophageal cancer
- obesity due to melanocortin 4 receptor deficiency
- glycogen storage disease VI
- obesity due to pro-opiomelanocortin deficiency
- hyperinsulinism due to HNF1A deficiency
- obesity due to prohormone convertase I deficiency
- schizophrenia 15
- CIDEC-related familial partial lipodystrophy
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency
- obesity due to congenital leptin deficiency
- low phospholipid associated cholelithiasis
