SYCP3

Description

The SYCP3 gene encodes a protein crucial for the formation of the synaptonemal complex (SC), a protein structure essential for proper chromosome pairing and recombination during meiosis. Meiosis is a specialized cell division process that produces gametes (sperm and egg cells), ensuring genetic diversity in offspring. The SC acts as a scaffold, holding homologous chromosomes together, facilitating genetic exchange between them. Defects in SYCP3 function can disrupt this process, leading to infertility in males.

Associated Diseases

• Male infertility
• Spermatogenic failure-4
• Azoospermia (absence of sperm in semen)
• Oligospermia (low sperm count)
• Asthenozoospermia (poor sperm motility)

Did you know?

Mutations in the SYCP3 gene are one of the most common causes of male infertility due to meiotic defects.