ZFYVE26 : zinc finger FYVE-type containing 26

Description

The ZFYVE26 (zinc finger FYVE-type containing 26) is a protein-coding gene located on chromosome 14.

The ZFYVE26 gene provides instructions for creating a protein called spastizin, which is present in most tissues. Spastizin is crucial for autophagy, a process where worn-out cell parts and unnecessary proteins are recycled within cells. Specifically, spastizin is involved in the formation and maturation of autophagosomes, sacs that enclose materials needing recycling. The autophagosome then fuses with a lysosome, a cellular structure responsible for breaking down and recycling the materials. Aside from clearing cells of unwanted materials, spastizin also plays a role in ensuring proper cell division. During the final stages of cell division, spastizin participates in the process of cytokinesis, where dividing cells separate from one another.

ZFYVE26 is also known as FYVE-CENT, SPG15.

Associated Diseases

• Autosomal recessive spastic paraplegia type 15
• Spastic paraplegia 15, autosomal recessive
• Spastic paraplegia type 15