WNT7A
Description
The WNT7A gene, located on chromosome 3, plays a crucial role in various developmental processes, particularly in the formation of organs and tissues. It encodes a protein that acts as a signaling molecule, influencing cell growth, differentiation, and migration. WNT7A's activity is essential for proper limb development, hair follicle formation, and the development of other vital organs. Dysregulation of WNT7A signaling can lead to developmental abnormalities and disease.
Associated Diseases
- Brachydactyly (short fingers or toes)
- Amelia (absence of limbs)
- Ectrodactyly (split hand/foot malformation)
- Congenital heart defects
- Hair loss disorders
- Cancer (especially breast and colon cancer)
Did you know?
WNT7A is named after the 'wingless' gene in Drosophila flies, which was the first gene discovered in this signaling pathway.
