WBP2
Description
The WBP2 (WW domain binding protein 2) is a protein-coding gene located on chromosome 17.
WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene. The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.
WBP2 acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In the presence of estrogen, WBP2 binds to ESR1-responsive promoters. WBP2 is required for YAP1's coactivation function on PGR activity. It synergizes with WBP2 in enhancing PGR activity. WBP2 modulates the expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2, and PGR.
WBP2 is also known as DFNB107, GRAMD6, WBP-2.
