WARS2

Description

The WARS2 gene, located on chromosome 17, encodes a protein known as tryptophanyl-tRNA synthetase 2. This protein plays a vital role in the intricate process of ribosome biogenesis, specifically in the synthesis of transfer RNA (tRNA). tRNAs act as molecular adapters, translating genetic information from messenger RNA (mRNA) into proteins. WARS2 is responsible for attaching the amino acid tryptophan to its corresponding tRNA, ensuring accurate protein synthesis. Mutations in WARS2 can disrupt this process, leading to various cellular dysfunctions.

Associated Diseases

• Diamond-Blackfan Anemia (DBA)
• Myelodysplastic Syndrome (MDS)
• Neurodevelopmental Disorders
• Congenital Malformations

Did you know?

WARS2 is a highly conserved gene across different species, indicating its essential role in fundamental biological processes.