VPS51
Description
The VPS51 (VPS51 subunit of GARP complex) is a protein-coding gene located on chromosome 11.
Vacuolar protein sorting-associated protein 51 homolog, also known as Another new gene 2 protein and Protein fat-free homolog, is a protein that in humans is encoded by the VPS51 gene. This protein plays a key role in intracellular transport, particularly in the retrograde transport of molecules from endosomes back to the Golgi apparatus. It is a component of two major protein complexes: the GARP complex and the EARP complex. The GARP complex is involved in various cellular processes, including the retrieval of proteins from endosomes to the TGN, the sorting of acid hydrolases, the maintenance of lysosome function, the regulation of endosomal cholesterol trafficking, and autophagy. VPS51 specifically participates in the retrograde transport of acid hydrolase receptors, likely by facilitating the attachment and fusion of vesicles carrying these receptors to the TGN. The EARP complex, on the other hand, is involved in endocytic recycling and associates with Rab4-positive endosomes to promote the recycling of internalized transferrin receptors back to the plasma membrane. VPS51 interacts with various proteins, including STX6, VPS50, and VPS54, and its association with the GARP complex is mediated by EIPR1.
VPS51 is also known as ANG2, ANG3, C11orf2, C11orf3, FFR, PCH13.
