TRHR

Description

The TRHR gene, encoding thyrotropin-releasing hormone receptor (TRHR), plays a pivotal role in regulating thyroid hormone production. TRHR is a G protein-coupled receptor located on the pituitary gland, where it binds to thyrotropin-releasing hormone (TRH). This binding triggers a cascade of events leading to the release of thyroid-stimulating hormone (TSH), which in turn stimulates thyroid hormone production by the thyroid gland. The intricate interplay of these hormones ensures a proper balance of thyroid function, influencing various physiological processes like metabolism, growth, and development.

Associated Diseases

• Hypothyroidism: Deficient thyroid hormone production, often due to TRHR mutations or dysfunction.
• Hyperthyroidism: Excessive thyroid hormone production, sometimes caused by TRHR overactivity or autoimmune disorders.
• Congenital Hypothyroidism: Present at birth, can result from TRHR defects, leading to developmental delays and other complications.

Did you know?

TRHR is also found in the brain, where it influences mood, sleep, and appetite.