TRAK1
Description
The TRAK1 (trafficking kinesin protein 1) is a protein-coding gene located on chromosome 3.
Trafficking kinesin-binding protein 1 is a protein that in humans is encoded by the TRAK1 gene.
Trafficking kinesin-binding protein 1 (TRAK1) plays a crucial role in regulating the movement of cellular components within cells, particularly in the transport of mitochondria and endosomes. It participates in the process of endosome-to-lysosome trafficking, influencing the movement of complexes like EGF-EGFR and GABA-A receptors. TRAK1 is also involved in mitochondrial motility, acting as a key factor in the movement of mitochondria within cells. Interestingly, when TRAK1 is glycosylated, it disrupts mitochondrial motility. Additionally, TRAK1 is essential for recruiting the enzyme OGT to the surface of mitochondria in neuronal cells, facilitating the proper functioning of mitochondria in these cells. Further, TRAK1 interacts with RHOT to form a vital complex that connects KIF5 to mitochondria, enabling the independent transport of mitochondria. Notably, TRAK1 interacts with a variety of proteins, including RHOT1, RHOT2, HGS, GABRA1, and KIF5C, underscoring its multifaceted role in cellular processes.
TRAK1 is also known as DEE68, EIEE68, MILT1, OIP106.
