TLE6
Description
The TLE6 (TLE family member 6, subcortical maternal complex member) is a protein-coding gene located on chromosome 19.
TLE6, also known as Transducin-like enhancer protein 6, is a protein that in humans is encoded by the TLE6 gene. This gene is located on chromosome 7 and contains 9 exons that encode for a protein of 1233 amino acids. TLE6 is a member of the Groucho/TLE family of transcriptional corepressors, a group of proteins that repress gene expression by interacting with various transcription factors. TLE6 is involved in a variety of cellular processes, including spermatogonia proliferation, cell cycle progression, neuronal differentiation, and early embryonic development. It interacts with various proteins, including FOXG1, NFATC1, and PAX6, to regulate their activity and modulate gene expression.
TLE6 plays a role in regulating cell division and differentiation. It controls the growth and division of spermatogonia, possibly by influencing genes like CEBPB, CEBPA, CSF3, PCNA, and CDK4. TLE6 also acts to reduce the suppression of gene expression by FOXG1, a protein involved in the development of brain cells. It does this by preventing TLE1, another protein, from interacting with FOXG1. Finally, TLE6 helps to repress gene expression controlled by NFATC1 by cooperating with PAX6.
TLE6 is also known as GRG6, OZEMA15, PREMBL.
