TECR
Description
The TECR (trans-2,3-enoyl-CoA reductase) is a protein-coding gene located on chromosome 19.
TECR (Trans-2,3-enoyl-CoA reductase) is a human gene that encodes a multi-pass membrane protein residing in the endoplasmic reticulum. It belongs to the steroid 5-alpha reductase family. TECR plays a critical role in the final step of the elongation of microsomal long and very long chain fatty acids, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. This protein is involved in the production of very long-chain fatty acids (VLCFAs) that are crucial for sphingolipid synthesis. Mutations in TECR have been linked to non-syndromic mental retardation.
TECR plays a crucial role in both the synthesis of very long-chain fatty acids (VLCFAs) for sphingolipid production and the breakdown of the sphingosine component of sphingolipids via the sphingosine 1-phosphate metabolic pathway. It catalyzes the final step in the four-reaction long-chain fatty acid elongation cycle, adding two carbons to long- and very long-chain fatty acids per cycle. TECR reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA, enabling further elongation through repeated cycles. This process contributes to the production of VLCFAs with varying chain lengths, which are essential precursors for membrane lipids and lipid signaling molecules. Additionally, TECR catalyzes the saturation step in the sphingosine 1-phosphate metabolic pathway, converting trans-2-hexadecenoyl-CoA to palmitoyl-CoA.
TECR is also known as GPSN2, MRT14, SC2, TER.
