STK36
Description
The STK36 (serine/threonine kinase 36) is a protein-coding gene located on chromosome 2.
Serine/threonine-protein kinase 36 is an enzyme encoded by the STK36 gene in humans. It has been shown to interact with GLI1.
STK36, also known as Fused homolog, plays a critical role in the sonic hedgehog (Shh) signaling pathway. It regulates the activity of GLI transcription factors, particularly GLI1, GLI2, and GLI3. STK36 counteracts the inhibitory effects of SUFU, promoting the nuclear localization of GLI proteins. While GLI2 requires STK36 to become transcriptionally active, this activity does not necessitate an active kinase catalytic site within the enzyme. STK36 is essential for postnatal development, potentially by regulating cerebrospinal fluid homeostasis and ciliary function. It plays a key role in building the central pair apparatus of motile cilia.
STK36 is also known as CILD46, FU.
