SMO

Description

The SMO (smoothened, frizzled class receptor) is a protein-coding gene located on chromosome 7.

SMO or Smo may refer to:

SMO is a G protein-coupled receptor that works in conjunction with the patched protein (PTCH) to relay hedgehog protein signaling. When sonic hedgehog (SHH) binds to PTCH, it disrupts PTCH's inhibition of SMO, activating SMO. In its active state, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA from phosphorylating GLI transcription factors. This release of GLI proteins from PRKACA-mediated inhibition allows for the activation of hedgehog pathway target genes. SMO is essential for the accumulation of KIF7, GLI2, and GLI3 in cilia. It interacts with DLG5 at the ciliary base, which promotes the accumulation of KIF7 and GLI2 at the ciliary tip, activating GLI2.

SMO is also known as CRJS, FZD11, Gx, PHLS, SMOH.

Associated Diseases

• Curry-Jones syndrome
• Basal cell carcinoma, susceptibility to, 1
• Pallister-Hall-like syndrome
• Hirschsprung disease
• Meningioma