SLC25A10
Description
The SLC25A10 gene encodes a mitochondrial transporter protein known as the dicarboxylate carrier (DIC). This protein plays a vital role in cellular energy production by mediating the exchange of dicarboxylate anions, such as malate and succinate, across the mitochondrial inner membrane. This exchange is essential for the proper functioning of the citric acid cycle and oxidative phosphorylation, the primary pathways for ATP generation within mitochondria.
Associated Diseases
- Mitochondrial disorders: Mutations in SLC25A10 have been linked to various mitochondrial diseases, including Leigh syndrome, a neurodegenerative disorder characterized by brain dysfunction.
- Cardiomyopathy: Impaired mitochondrial function due to SLC25A10 mutations can contribute to cardiomyopathy, a condition affecting the heart muscle.
- Other metabolic disorders: Variations in SLC25A10 have been associated with other metabolic disorders, such as diabetes and obesity.
Did you know?
SLC25A10 is a highly conserved gene, meaning its sequence and function are similar across a wide range of organisms, highlighting its fundamental importance in cellular metabolism.
