SAG
Description
The SAG (S-antigen visual arrestin) is a protein-coding gene located on chromosome 2.
SAG, SAg, or sag can refer to various things.
SAG binds to activated and phosphorylated rhodopsin (RHO) and stops its signaling through G-proteins by outcompeting them for the same binding site on RHO. This suggests SAG might play a role in safeguarding retinal photoreceptor cells from light-induced damage.
SAG is also known as RP47, RP96, S-AG.
Associated Diseases
- Retinitis pigmentosa
- Oguchi disease
- Retinitis pigmentosa 47
- Retinitis pigmentosa 96, autosomal dominant
- Congenital stationary night blindness
- Oguchi disease 1
