PI4KA
Description
PI4KA (phosphatidylinositol 4-kinase alpha) is a gene encoding an enzyme that plays a crucial role in phosphoinositide metabolism. Phosphoinositides are essential signaling molecules involved in various cellular processes, including membrane trafficking, cytoskeletal organization, and cell growth. PI4KA specifically catalyzes the phosphorylation of phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P), a key intermediate in the synthesis of other phosphoinositides. PI4P is involved in diverse cellular functions, such as regulating membrane trafficking, cytoskeleton organization, and intracellular signaling.
Associated Diseases
- Cancer (e.g., breast cancer, prostate cancer, lung cancer)
- Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)
- Cardiovascular diseases (e.g., atherosclerosis)
- Immune disorders (e.g., lupus)
Did you know?
Mutations in the PI4KA gene have been linked to various human diseases, highlighting its crucial role in maintaining cellular health.
