PDHB : pyruvate dehydrogenase E1 subunit beta
Description
The PDHB (pyruvate dehydrogenase E1 subunit beta) is a protein-coding gene located on chromosome 3.
The PDHB gene provides instructions for making a protein called E1 beta. E1 beta is a subunit of a larger protein: two E1 beta proteins combine with two copies of another protein, called E1 alpha (produced from the PDHA1 gene), to form the E1 enzyme. This enzyme, also known as pyruvate dehydrogenase, is a component of a group of proteins called the pyruvate dehydrogenase complex. The pyruvate dehydrogenase complex plays an important role in the pathways that convert the energy from food into a form that cells can use. This complex converts a molecule called pyruvate, which is formed from the breakdown of carbohydrates, into another molecule called acetyl-CoA. The E1 enzyme performs one part of this chemical reaction. The conversion of pyruvate is essential to begin the series of chemical reactions that produces adenosine triphosphate (ATP), the cell's main energy source.
PDHB is also known as E1beta, PDHBD, PDHE1-B, PDHE1B, PHE1B.
