PCIF1

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Description

PCIF1, also known as the ‘PCNA-interacting factor 1‘, is a crucial gene involved in regulating the cell cycle and maintaining genomic stability. It plays a vital role in DNA replication and repair processes by interacting with various proteins, including PCNA (proliferating cell nuclear antigen) and CHK1 (checkpoint kinase 1). This interaction enables PCIF1 to control the progression of the cell cycle, ensuring accurate DNA replication and preventing errors that could lead to mutations and cancer. Disruptions in PCIF1 function have been linked to several diseases, highlighting its significance in maintaining cellular integrity.

Associated Diseases

• Cancer (particularly colorectal, breast, and lung cancer)
• Neurodevelopmental disorders (e.g., autism spectrum disorder)
• Immune system dysfunction

Did you know?

PCIF1 exhibits a unique ability to switch between different functional states, enabling it to regulate various aspects of DNA replication and repair.