NIN
Description
The NIN (ninein) is a protein-coding gene located on chromosome 14.
NIN, or Ninein, is a human gene. It refers to a protein known as Ninein (hNinein) or Glycogen synthase kinase 3 beta-interacting protein. This protein plays a crucial role in the organization of microtubules within cells, particularly in epithelial cells. It is involved in the positioning and anchoring of microtubules, acting as a potential centrosome maturation factor. NIN also contributes to microtubule nucleation by recruiting the gamma-tubulin ring complex to the centrosome.
NIN is a centrosomal protein essential for proper microtubule organization in epithelial cells. It helps position and anchor the minus-end of microtubules, potentially functioning as a centrosome maturation factor. NIN plays a role in microtubule nucleation by recruiting the gamma-tubulin ring complex to the centrosome. While overexpression does not affect microtubule nucleation or elongation, it does suppress microtubule release. Additionally, NIN is crucial for centriole organization and microtubule anchoring at the mother centriole.
NIN is also known as SCKL7.
