NCAPH
Description
The NCAPH (non-SMC condensin I complex subunit H) is a protein-coding gene located on chromosome 2.
NCAPH (Non-SMC condensin I complex subunit H), also known as CAP-H (Chromosome-associated protein H) or Condensin complex subunit 2, is a protein encoded by the NCAPH gene in humans. It's a subunit of condensin I, a large protein complex involved in chromosome condensation. NCAPH belongs to the barr protein family and functions as a regulatory subunit of the condensin complex. This complex is crucial for transforming interphase chromatin into condensed chromosomes. NCAPH is associated with mitotic chromosomes, except during the early phase of chromosome condensation. In interphase, it exhibits a distinct punctate nucleolar localization. As a key subunit of the conserved SMC condensin I complex in eukaryotes, NCAPH interacts with NCAPG, NCAPD2, and the N and C termini of the SMC-4 and SMC-2 proteins. It acts as a kleisin protein, bridging the head groups of the SMC proteins. The interaction between NCAPH and the globular ATPase head binding sites on the C and N termini of the SMC heterodimer enables condensin's dynamic properties. Abnormal expression of NCAPH might be linked to various types of carcinogenesis as a prognostic indicator.
NCAPH is also known as BRRN1, CAP-H, CAPH, MCPH23, NCAPH1.
