MINPP1

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Description

The MINPP1 (multiple inositol-polyphosphate phosphatase 1) is a protein-coding gene located on chromosome 10.

Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.

MINPP1, also known as 2,3-bisphosphoglycerate 3-phosphatase, hydrolyzes inositol polyphosphates like InsP5[2OH] and InsP6, producing less phosphorylated inositol phosphates. This regulates the levels of these second messengers and metal chelators, impacting cell physiology. While it exhibits weak activity towards Ins(1,4,5)P3 in vitro, this is likely not physiologically relevant. MINPP1 also acts as a 2,3-bisphosphoglycerate 3-phosphatase, converting 2,3-bisphosphoglycerate to 2-phosphoglycerate. This activity is linked to the Rapoport-Luebering glycolytic bypass and regulation of systemic oxygen homeostasis through its influence on hemoglobin.

MINPP1 is also known as HIPER1, MINPP2, MIPP, PCH16.

Associated Diseases

• Pontocerebellar hypoplasia, type 16
• Pontocerebellar hypoplasia type 7
• Familial papillary or follicular thyroid carcinoma
• Thyroid cancer, nonmedullary, 2