LIPC : lipase C, hepatic type
Description
The LIPC gene, located on chromosome 15, encodes for hepatic lipase (HL), an enzyme crucial for lipid metabolism. HL primarily functions in the breakdown of triglyceride-rich lipoproteins (TRLs) and high-density lipoproteins (HDLs). It plays a critical role in regulating lipoprotein lipase (LPL) activity, facilitating the delivery of lipids to peripheral tissues. HL's actions contribute to the removal of cholesterol from the bloodstream, impacting cholesterol levels and cardiovascular health.
Associated Diseases
- Familial LPL deficiency (FDLP): HL deficiency can lead to reduced LPL activity, causing severe hypertriglyceridemia.
- Hypercholesterolemia: Elevated cholesterol levels may be linked to HL deficiency, contributing to the risk of cardiovascular disease.
- Atherosclerosis: Reduced HL activity can lead to increased LDL (bad cholesterol) levels, promoting plaque buildup in arteries.
- Cardiovascular disease: HL deficiency is associated with an increased risk of heart attacks and strokes.
Did you know?
Studies suggest that the LIPC gene's activity can be influenced by factors like diet, exercise, and even genetics.
