LAT
Description
The LAT (linker for activation of T cells) is a protein-coding gene located on chromosome 16.
LAT, or Linker of Activated T cells, is a gene involved in T-cell signaling. It plays a role in the activation of T-cells, which are important for the immune system. LAT is also involved in signaling pathways in natural killer cells and mast cells.
The LAT gene is essential for signaling pathways triggered by the T-cell receptor (TCR) and pre-TCR, both in mature T cells and during their development. This gene is involved in signaling cascades initiated by FCGR3 (low affinity immunoglobulin gamma Fc region receptor III) in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor) in mast cells. It facilitates the communication between these receptors and their associated kinases, leading to downstream events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation, and cytoskeletal reorganization. This is achieved through the recruitment of signaling molecules like PLCG1, GRB2, and GRAP2. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}
LAT is also known as IMD52, LAT1, pp36.
