KIF14
Description
The KIF14 (kinesin family member 14) is a protein-coding gene located on chromosome 1.
Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.
KIF14 is a microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has ATPase activity. It plays a role in various cellular processes, including cell division, cytokinesis, cell proliferation, and apoptosis. During cytokinesis, KIF14 targets to the central spindle and midbody via interactions with PRC1 and CIT, respectively. It regulates cell growth by controlling cell cycle progression and cytokinesis, acting through the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process to regulate CDKN1B degradation and positively regulate cyclins (CCNE1, CCND1, and CCNB1). During late neurogenesis, KIF14 regulates cerebellar, cerebral cortex, and olfactory bulb development by controlling apoptosis, cell proliferation, and cell division. It is required for chromosome congression and alignment during mitotic cell cycle processes. KIF14 also regulates cell spreading, focal adhesion dynamics, and cell migration through interaction with RADIL, which in turn regulates RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules.
KIF14 is also known as MCPH20, MKS12.
Associated Diseases
- Autosomal recessive primary microcephaly
- Microcephaly 20, primary, autosomal recessive
- Meckel syndrome 12
