IFT57
Description
The IFT57 (intraflagellar transport 57) is a protein-coding gene located on chromosome 3.
Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.
== Interactions == IFT57 has been shown to interact with Caspase 8.
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
IFT57 is also known as ESRRBL1, HIPPI, MHS4R2, OFD18.
