DIS3L2
Description
The DIS3L2 (DIS3 like 3'-5' exoribonuclease 2) is a protein-coding gene located on chromosome 2.
DIS3L2 is a human protein encoded by the DIS3L2 gene. Its sequence is similar to the 3'/5' exonucleolytic subunits of the RNA exosome, a multimeric complex responsible for degrading various RNA substrates. DIS3L2 has several transcript variants, some coding for proteins and others not. Mutations in DIS3L2 cause Perlman syndrome.
DIS3L2 is a 3'-5' exoribonuclease that specifically targets and degrades RNAs with a polyuridylated 3' end. It acts independently of the exosome complex, degrading both mRNAs and miRNAs that have been polyuridylated by terminal uridylyltransferases like ZCCHC11/TUT4. DIS3L2 degrades cytoplasmic mRNAs that have undergone deadenylation followed by uridylation at their 3' end. It also degrades uridylated pre-let-7 miRNAs, which is crucial for maintaining embryonic stem (ES) cell function. DIS3L2 is essential for proper mitosis and negatively regulates cell proliferation.
DIS3L2 is also known as FAM6A, PRLMNS, hDIS3L2.
