CTSF
Description
The CTSF gene encodes cathepsin F, a lysosomal protease crucial for the breakdown of proteins within cells. It plays a vital role in diverse cellular processes, including antigen processing, immune response regulation, and tissue remodeling. Cathepsin F exhibits a broad substrate specificity, targeting various proteins involved in inflammation, cell signaling, and extracellular matrix degradation. Its activity is tightly regulated to ensure proper protein turnover and prevent uncontrolled degradation. Dysregulation of CTSF expression or activity has been linked to several pathological conditions.
Associated Diseases
- Cancer (e.g., breast cancer, prostate cancer)
- Neurodegenerative diseases (e.g., Alzheimer‘s disease, Parkinson‘s disease)
- Inflammatory disorders (e.g., rheumatoid arthritis, inflammatory bowel disease)
- Cardiovascular disease
- Lysosomal storage disorders
Did you know?
Cathepsin F is found in a variety of tissues throughout the body, with particularly high levels in the liver, spleen, and brain.
