CTNNA2
Description
The CTNNA2 (catenin alpha 2) is a protein-coding gene located on chromosome 2.
Catenin alpha-2, also known as αN-catenin, is a type of α-catenin protein that in humans is encoded by the CTNNA2 gene.
CTNNA2, also known as αN-catenin, plays a crucial role in cell-cell adhesion and differentiation within the nervous system. It acts as a bridge between cadherin adhesion receptors and the cytoskeleton, regulating key processes like cortical neuronal migration and neurite growth. CTNNA2 negatively regulates Arp2/3 complex activity and actin polymerization, preventing excessive actin branching that could hinder neurite growth and stability. Additionally, it contributes to the morphological plasticity of synapses and the proper development of cerebellar and hippocampal laminae. It also influences the modulation of startle responses.
CTNNA2 is also known as CAP-R, CAPR, CDCBM9, CT114, CTNR.
