CP : ceruloplasmin
Description
The CP (ceruloplasmin) is a protein-coding gene located on chromosome 3.
The CP gene provides instructions for making ceruloplasmin, a protein that helps move iron from the body's organs and tissues into the blood. Ceruloplasmin prepares iron for incorporation into transferrin, a molecule that transports iron to red blood cells. Two forms of ceruloplasmin exist. Serum ceruloplasmin, primarily made in the liver, is involved in iron transport from most of the body, but cannot enter the brain. The GPI-anchored form, synthesized by glia in the nervous system, is crucial for iron processing and release within the brain.
Ceruloplasmin is a multifunctional protein with a wide range of activities, including ferroxidase activity, copper ion oxidation, and glutathione peroxidase-like activity. It is involved in iron transport, oxidation of biogenic amines, and deaminase degradation of heparan sulfate chains. Ceruloplasmin also shows NO-oxidase and NO2 synthase activities, contributing to endocrine NO homeostasis. (UniProtKB:P13635, PubMed:10481051, PubMed:14623105, PubMed:16150804, PubMed:16906150, PubMed:5912351)
CP is also known as AB073614, CP-2.
