CDT1 : chromatin licensing and DNA replication factor 1
Description
The CDT1 (chromatin licensing and DNA replication factor 1) is a protein-coding gene located on chromosome 16.
The CDT1 gene provides instructions for making a protein that is essential for copying a cell's DNA before it divides, a process known as DNA replication. This protein is a part of the pre-replication complex, which binds to specific DNA regions called origins of replication, marking the starting points for DNA copying. The CDT1 protein plays a crucial role in the formation of this complex, ensuring that DNA replication occurs only once per cell division, a process known as replication licensing. This process is vital for normal cell division.
CDT1, also known as Double parked homolog, plays a critical role in both DNA replication and mitosis. It functions as a DNA replication licensing factor, essential for the assembly of the pre-replication complex. During the G1 phase of the cell cycle, CDT1 collaborates with CDC6 and the origin recognition complex (ORC) to facilitate the loading of the MCM complex onto DNA, leading to the formation of pre-replication complexes (pre-RCs). This process ensures that DNA replication occurs only once per cell cycle. Additionally, CDT1 is crucial for mitosis by promoting stable kinetochore-microtubule attachments. Notably, CDT1 has been identified as a potential oncogene due to its involvement in cell cycle regulation. Evidence supporting its involvement in DNA replication and mitosis has been reported in multiple studies, including PubMed IDs 11125146, 14993212, 21856198, 22581055, and 26842564.
CDT1 is also known as DUP, RIS2.
