CAVIN1 : caveolae associated protein 1
Description
The CAVIN1 (caveolae associated protein 1) is a protein-coding gene located on chromosome 17.
The CAVIN1 gene provides instructions for making a protein called cavin-1, which is found in cells and tissues throughout the body. It is particularly abundant in osteoblasts, muscle cells, and adipocytes. Cavin-1 plays a crucial role in forming and stabilizing caveolae, small pouches in the cell membrane that are involved in various functions, including transport, processing, and storage of molecules. In addition to its role in caveolae, cavin-1 is involved in repairing cell membrane damage, cell growth and division, cell movement, stopping cell division in older cells, and regulating chemical signaling pathways. The specific functions of cavin-1 likely vary depending on the cell type and its location within the cell.
Cavin-1 is a key player in the formation and organization of caveolae, small membrane pouches essential for various cellular processes. It is crucial for the formation of caveolae in all tissues. Cavin-1 is a core component of the CAVIN complex, which is essential for the recruitment of the complex to caveolae in the presence of caveolin-1 (CAV1). This protein is also vital for the proper oligomerization of CAV1. Furthermore, Cavin-1 promotes ribosomal transcriptional activity in response to metabolic challenges in adipocytes. It plays a crucial role in the formation of the ribosomal transcriptional loop and dissociates transcription complexes paused by DNA-bound TTF1. This release allows RNA polymerase I and pre-RNA to detach from the template. The caveolae biogenesis pathway, which Cavin-1 is involved in, is necessary for the secretion of proteins such as GASK1A.
CAVIN1 is also known as CAVIN, CGL4, FKSG13, PTRF, cavin-1.
