BLNK

Description

The BLNK gene, also known as B-cell linker protein, plays a pivotal role in the immune system. It encodes a protein that acts as a crucial adapter molecule, facilitating communication between various components of the signaling pathways involved in B-cell activation and development. BLNK protein interacts with several other proteins, including kinases, phosphatases, and transcription factors, enabling the proper transmission of signals that ultimately lead to immune responses.

Associated Diseases

• X-linked agammaglobulinemia (XLA)
• Common variable immunodeficiency (CVID)
• Autoimmune disorders (e.g., systemic lupus erythematosus)
• Cancer (e.g., lymphoma, leukemia)

Did you know?

Mutations in the BLNK gene can lead to severe immunodeficiency disorders, rendering individuals highly susceptible to infections.