BANF1
Description
The BANF1 gene, also known as barrier-to-autointegration factor 1, plays a crucial role in regulating various cellular processes. It encodes a protein that acts as a scaffold, helping to organize and stabilize chromatin, the complex of DNA and proteins that makes up chromosomes. This organization is essential for proper gene expression, DNA replication, and cell division. BANF1 also participates in the regulation of transcription, the process by which genetic information is converted into functional proteins.
Associated Diseases
- Cancer: Mutations in BANF1 have been linked to an increased risk of certain cancers, particularly those affecting the liver, breast, and colon.
- Neurodevelopmental Disorders: Aberrant BANF1 expression has been associated with neurodevelopmental disorders like autism spectrum disorder and intellectual disability.
- Cardiovascular Diseases: Some studies suggest a potential link between BANF1 dysregulation and cardiovascular diseases, including atherosclerosis.
- Immune Disorders: BANF1‘s role in immune cell function may contribute to the development of autoimmune disorders.
Did you know?
BANF1 was initially discovered for its ability to block the integration of retroviruses into the host genome. This suggests a possible role in the regulation of viral infections.
