ARMC9
Description
The ARMC9 (armadillo repeat containing 9) is a protein-coding gene located on chromosome 2.
ARMC9 is a protein encoded by the ARMC9 gene in humans. It contains a LisH domain and is involved in ciliogenesis. ARMC9 is required for appropriate acetylation and polyglutamylation of ciliary microtubules and regulates cilium length. ARMC9 also acts as a positive regulator of hedgehog (Hh) signaling and may be involved in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip.
ARMC9 plays a crucial role in ciliogenesis, ensuring proper acetylation and polyglutamylation of ciliary microtubules, which in turn regulates cilium length (PubMed:32453716). Furthermore, ARMC9 acts as a positive regulator of hedgehog (Hh) signaling (By similarity). It is suspected that ARMC9 may be involved in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity). These functions are supported by interactions with TOGARAM1, CCDC66, CEP104, CSPP1, and CEP290.
ARMC9 is also known as ARM, JBTS30, KU-MEL-1, NS21.
