ARHGDIA

Description

The ARHGDIA gene encodes Rho GDP dissociation inhibitor alpha (RhoGDIα), a crucial protein involved in the regulation of Rho GTPases. Rho GTPases are small GTP-binding proteins that act as molecular switches, controlling a wide array of cellular processes, including cell growth, migration, and cytoskeletal organization. RhoGDIα acts as a negative regulator of Rho GTPases, sequestering them in an inactive state in the cytoplasm. This control over Rho GTPase activity is essential for maintaining normal cellular function and preventing uncontrolled cell growth and proliferation.

Associated Diseases

• Cancer (e.g., leukemia, breast cancer, colorectal cancer)
• Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)
• Cardiovascular diseases (e.g., atherosclerosis, hypertension)
• Immune disorders (e.g., autoimmune diseases)

Did you know?

ARHGDIA gene expression is often dysregulated in cancer cells, contributing to their uncontrolled growth and spread.