ARG1 : arginase 1
Description
The ARG1 gene, encodes arginase 1, a key enzyme involved in the urea cycle. This cycle removes excess ammonia from the body, a toxic byproduct of protein metabolism. Arginase 1 catalyzes the hydrolysis of arginine, converting it into ornithine and urea. This process is essential for maintaining nitrogen homeostasis and regulating arginine levels. Arginase 1 plays a role in various physiological processes, including immune response, wound healing, and blood pressure regulation. Its activity is tightly regulated by factors like nitric oxide and growth factors.
Associated Diseases
- Hyperargininemia: A rare genetic disorder characterized by elevated arginine levels in the blood due to ARG1 deficiency
- Urea cycle disorders: ARG1 mutations can contribute to urea cycle defects, leading to ammonia accumulation and neurological complications
- Cancer: Altered ARG1 expression and activity have been linked to cancer progression and treatment response in various cancers
- Cardiovascular disease: Arginase 1 is implicated in cardiovascular disease, potentially contributing to blood pressure regulation and vascular function
Did you know?
Arginine is a conditionally essential amino acid, meaning our bodies can synthesize it under normal circumstances, but its production may become insufficient under certain conditions, making dietary intake necessary.
