APOA1 : apolipoprotein A1

Description

The APOA1 gene provides instructions for making apolipoprotein A-I, a major protein component of high-density lipoprotein (HDL), often referred to as 'good' cholesterol. HDL plays a crucial role in transporting cholesterol from the body's tissues back to the liver for processing and excretion. APOA1 is vital for maintaining healthy cholesterol levels and preventing heart disease. Variations in the APOA1 gene can affect HDL levels and an individual's risk for heart disease.

Associated Diseases

• Familial HDL Deficiency (Tangier Disease)
• Atherosclerosis
• Coronary Artery Disease
• Cardiovascular Disease

Did you know?

People with Tangier disease, a rare genetic disorder caused by mutations in the APOA1 gene, have extremely low levels of HDL and accumulate cholesterol in their tissues, leading to enlarged tonsils, orange-colored tonsils, and an increased risk of heart disease.