ANAPC7
Description
The ANAPC7 (anaphase promoting complex subunit 7) is a protein-coding gene located on chromosome 12.
ANAPC7 is a human gene that encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase. APC/C plays a crucial role in cell cycle progression by targeting cell cycle regulators, such as B-type cyclins, for degradation via ubiquitination. ANAPC7 is essential for the proper ubiquitination function of APC/C and for its interaction with certain transcription coactivators. ANAPC7 has been shown to interact with several other proteins, including ANAPC1, ANAPC4, CDC27, and CDC20.
ANAPC7 is a subunit of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle regulator that controls progression through mitosis and the G1 phase. APC/C acts by ubiquitinating and degrading target proteins, primarily forming Lys-11-linked polyubiquitin chains, and to a lesser extent, Lys-48- and Lys-63-linked chains. While not essential for APC/C assembly, ANAPC7 acts as an enzyme-substrate adapter, facilitating the processive ubiquitination of specific substrates. Notably, ANAPC7 plays a role in brain development by ubiquitinating and removing MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis.
ANAPC7 is also known as APC7, FERBON.
